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There is some evidence that the risk of progression in patients with LGD confirmed by expert gastrointestinal pathologists may be higher

N Engl J Med, 2022

What is most important is staying consistent and following the protocol assigned by the provider since steady adherence leads to the best long-term outcomes

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As shown in the connected scatterplot in Figure 5 (top), the Sucrosomial B12 formulation rapidly raised circulatory vitamin B12 levels above the deficiency threshold, exceeding 300 pg/mL (borderline level) from day 1, and demonstrated a similar pattern of increasing circulatory vitamin B12 levels over time as observed in the KEMU and LRH studies cohorts, reaching a peak value of 592.7 74.3 at day 7, with all measurements throughout the week being significantly higher than baseline ( p 0.012)

However, higher doses increase cost without established evidence of proportionally increased benefit