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for 3 h and then concentrated under vacuum

at low concentrations (30-100 nM), it stimulates mitochondrial electron transport and cellular bioenergetics, while at higher concentrations (300 nM), it exerts an inhibitory effect on mitochondria

When GSH levels are chronically low, immune cells within the CNS shift to a damage-oriented phenotype

Despite their indispensability, amino acids are often scarce in the tumour microenvironment 4 , which drives tumours to develop strategies to import and synthesize them 5,6,7

Chen, I.-T., Hsu, P.-H., Hsu, W.-C., Chen, N.-J

In our experiments, the concentration of CB-839 needed for effective, functional glutaminase inhibition varied from 10 nM to 1 M, and the antiproliferative IC 50 was determined as 0.41 M for the HG-3 cell line and 66.2 M for the MEC-1 cell line