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In: Singh RS, Singhania RR, Pandey A, Larroche C (eds) Advances in enzyme technology

Intranasal RNs significantly improved RGC survival at approximately half the oral dose, thereby minimizing systemic exposure

Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

10.1038/s41419-022-05065-4 13 ChengB.ZhangJ.ShenQ.SunZ.LuoY.HuY

Not only is it more effective in increasing glutathione levels in the body, but it also has superior absorption and bioavailability

Mart-Andrs, P