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In the above reaction, Glutathione Peroxidase is the rate-limiting step of the entire reaction system, so the decrease in NADPH is linearly related to the activity of Glutathione Peroxidase

McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al

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Those with body mass indices above 30, or above 27 with weight-related health conditions, fall within the range studied in clinical trials

It works best as one part of a broader plan