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Similarly serotonergic neurons project from the raphe nucleus in the dentate gyrus while loss of 5-HT by neurotoxic lesions or synthesis inhibition results in reduced hippocampal proliferation that is rescued by implantation of fetal raphe neurons expressing 5-HT [128,129,130]

This led some authors to propose a chaperone competition model, in which aggregates, client, and metastable proteins (polyQ, huntingtin, ATXN1, and superoxide dismutase-1) rival for finite chaperone resources [64]

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Bjerre-Bastos, J