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However, ZD was observed in the hippocampus and cortex of the R6/1 mouse model of HD

This occurs through decreased mRNA expression of cartilage matrix synthesis genes ( Col2a1 and Acan ) and suppression of extracellular matrix signaling pathways, particularly transforming growth factor beta (Tgf)

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Until more rigorous research and clinical studies have been performed, BPC-157 should not be taken therapeutically

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