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batch-to-batch variation, contamination with pathogens or lead/arsenic, product- product variability users assume is uniform (but can be diverse within a supply chain), herb-drug interactions like modulating CYP enzymes that change the pharmacokinetics of drugs with narrow therapeutic windows all contribute to problems related to reproducibility and safety (195)

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1) Pharmacodynamics and Pharmacokinetics: To test the safety of a drug in humans, we must understand how the body processes the drug and what effects it has on the human body