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The initial step in heme breakdown involves the enzyme heme oxygenase ( HMOX ), which is active in reticuloendothelial system

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J Pineal Res 42:364370 Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cordaro S, Corona G, Trimarchi G, Barberi I (2001) Effects of melatonin treatment in septic newborns

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Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, et al

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Neuroscience (2009) 164:33143.10.1016/j.neuroscience.2009.03.080 43 BenedettiFBarbiniBBernasconiAFulgosiMCColomboCDallaspeziaSet alSerotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression

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Those with robust endogenous systems might gain less from antioxidant peptides (GHK-Cu) versus those with genetic limitations benefiting significantly

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