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Together, increased intraplaque cellular death and dysfunctional efferocytosis as a result of G6PD-d may accelerate plaque growth, necrotic core formation and the development of an inflammatory plaque microenvironment 106,107 (Fig
Wahab et al 7 conducted double-blind randomized controlled clinical trial evaluated the efficacy of topical and oral glutathione as skin-whitening agents
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3 The ferroptosis pathway 3.1 Definition and distinctive features Ferroptosis is a form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides, distinct from apoptosis, necroptosis, and autophagy
In general, NUPR1 is critical in regulating mitochondrial-related ferroptosis, either genetic or pharmacological inhibition of NUPR1 presents tumor-killing activity