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Start at the lower end of the dosing range to assess individual response

Within 48 hours after injection of 100 or 1000 mcg of vitamin B 12, 50 to 98% of the injected dose may appear in the urine

2.6 Investigating the mechanism of drug interaction by proteomic and phosphoproteomic analysis To elucidate the synergistic mechanism of our double and triple drug combinations, we examined the proteomics and phosphoproteomics changes in MNA Be(2)-C cells treated with DPI+/-MitoQ+/-Vin for 24 hours by mass spectrometry (MS)

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Data and Safety Monitoring Boards The DSMB comprises a paediatrician, public health expert and a biostatistician