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Finally, there are also data showing that even though serum IGF-I is acutely increased following prednisolone, this is not the case in lymph-like tissue fluid (107), suggesting that glucocorticoids exert distinct, compartment-specific effects on IGF-I action

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Paradigm shift from GTR concept to biologics application decreased the complication rate and improved the patient reported outcome measures [78, 79]

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