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"Like fasting," it said, "colonic cleansing carries a risk of dehydration, electrolyte imbalance, impaired bowel function, and disruption of intestinal flora." Edzard Ernst, professor of complementary medicine at Exeter University, called the concept of detoxing both a scandal and "criminal exploitation of the gullible man" in a 2014 interview with the Guardian

There is evidence to suggest that this hyper-metabolic state ultimately leads to beta cell exhaustion and overt diabetes mellitus (96), but it is also demonstrated that the abnormalities are completely reversed after successful surgery (95)

(7) These MC4R-sensitive circuits, potentially located in regions such as the paraventricular nucleus of the hypothalamus, might release endogenous oxytocin in response to Melanotan 2, possibly recalibrating imbalanced neurochemical activity thought to underlie key aspects of social impairment

But they're given to people for lipid issues

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