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Additionally, these same three polyamines may be produced in substantial amounts from Agm in the brain (Figure 1

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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

The Mann-Whitney U test was employed for variables not following a normal distribution