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In one study of people new to antipsychotics, those taking metformin saw significantly reduced weight gain, lower BMI , and improved insulin sensitivity

The stress response system also comes under DSIPs influence

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Serafini MM, Catanzaro M, Rosini M, Racchi M, Lanni C (2017) Curcumin in Alzheimers disease: can we think to new strategies and perspectives for this molecule

However, changes in GABAergic, cholinergic, noradrenergic, and serotonergic neurotransmission have also been identified as promoters of psychotic symptoms (11, 12)

J Chem Phys 81:36843690