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Dendrimers serve as vectors for natural products, offering controlled molecular structures, narrow polydispersity indices, and multiple functional groups [195, 196]

Another BBB-crossing molecule with HGF-like activity, BB3, was employed in pre-clinical models of stroke, showing good functional improvements (Chaparro et al., 2015)

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1 The sham group (n = 3) that had not been injected and treated with anything was sampled immediately after isoflurane anesthesia

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Briefly, the patients diagnosis was confirmed by biopsy, stained for amyloid using Congo red [51] and/or 99mTc-DPD, 3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy, and TTR mutation status was verified by PCR-based sequencing [52]