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First, a healthcare professional checks your symptoms and history

These agents act only before exposure to noxious substances, lacking therapeutic potential when administered after injury

Patients considering these treatments should understand the evidence base, safety considerations, and appropriate clinical indications before proceeding

Typical dosing is 0.2ml administered in the evening, on an empty stomach, five out of seven days of the week

A thin towel or cloth barrier prevents frostbite while still allowing cold to penetrate effectively

Injectable overdose is theoretically possible but would require dosages hundreds or thousands of times higher than research protocols