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These locally produced inflammatory mediators can directly affect neuronal function and synaptic transmission (Hinson et al., 2015)

[DOI] [PubMed] [Google Scholar] 112.Rius M., Nies A.T., Hummel-Eisenbeiss J., Jedlitschky G., Keppler D

In human ALS motor cortex, microglia show increased expression of Iba1 and CD68 (i.e., macrophages and monocytes marker), with CD68 levels strongly correlating with TDP-43 pathology (Swanson et al., 2023)

Abnormality in this cycle has been demonstrated to be related to deficiency of methylated B12 (James)

doi: 10.3390/v12101179 185 MordesD

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