Tachyphylaxis There are anecdotal reports suggesting tachyphylaxis, or loss of efficacy, of TCS over time, necessitating higher doses or more frequent applications [72, 89]
PMID: 34946716
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Consistent with the increases in NF-B binding activity, the protein levels of the two subunits were also increased upon TPA treatment in the samples from the basal diet group, and these increases were reduced in the Protandim diet group
The enzyme HO-1, encoded by the HMOX1 gene, catalyzes the conversion of heme into carbon monoxide, biliverdin, and free iron (as we discussed in Section NRF2 -HO-1 pathway)