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Methods : This study was observational with case-control, involving 25 patients with uncomplicated type 2 diabetes (receiving metformin and/or glimipiride) and 25 healthy controls

With the exception of a few classes such as GSTLs, DHARs and soluble CLICs that exist as monomeric enzymes (Figures 5A,B) (Dixon et al., 2002), other GSTs are mostly dimeric proteins and very often adopt the same dimerization mode

Recent research has shown that rhein can alleviate changes in the renal microstructure of model rats, and decrease the expression of apoptosis-related proteins, thereby reducing cell apoptosis, and counteracting the damage caused by oxidative stress to the kidneys (184)

Enhanced Stability : Modifications to its structure improve its efficacy and half-life, allowing for once-weekly dosing ( 6 )

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