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Groups 2 and 3 were blinded to the investigator, but not groups 1 and 4, where many islets from the two latter cases were either insulin-negative or showed reduced number of residual beta cells

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In the Yoshida hepatoma rat model[58], low-dose of IGF-I, delivered subcutaneously, reduced mortality and attenuated loss of body weight as well as muscle mass

Besides their central importance for the catabolic turnover of macromolecules, lysosomes also fulfill a critical anabolic function by serving as a recruitment platform for the multisubunit nutrient-sensing and signaling mechanistic target of rapamycin complex 1 (mTORC1), a major driver of anabolic programs, such as protein and lipid biosynthesis 4,5