In addition to the limited antioxidant defenses present in the nuclear region of the lens, another factor that could contribute to the susceptibility of this area of the lens to cataract may be the loss of -crystallin, 38 a major structural protein of the lens
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In the context of kava ingestion, there are several reports indicating its potential for the development of hepatotoxicity [8], skin rash [10], gastrointestinal problems and headaches [11], among other adverse effects that we address throughout this review
11, 12, Fig
This process occurs primarily in the liver and requires methylfolate along with vitamin B12