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10.1038/srep22831 209 LiaoB.ZhaoW.BeersD

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The mechanism involves: Cholinergic antagonism -- cortistatin reduces cortical arousal by antagonizing acetylcholine-mediated excitation, effectively dampening the wake-promoting cholinergic system that maintains cortical desynchronization during wakefulness EEG synchronization -- the transition from wakefulness to SWS is characterized by increasingly synchronized, high-amplitude delta waves on EEG

Mitra S, Behbahani H, Eriksdotter M

Understanding the IGF-1 system in neurons, including the regulation of IGF-1 availability and signaling mechanisms, could be an important aspect for development of ALS therapeutic approaches 14

Two safety topics deserve emphasis: TMAO and cardiovascular signals