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Studies also showed that OS is a mutual pathogenic factor of aging and major chronic diseases

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When there is an imbalance in the production of free radicals and the body's ability to combat them, oxidative stress arises

Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis

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(2017) CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway, Oncotarget , 8 , 114588-114602, doi: Lei, P., Bai, T., and Sun, Y