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To determine whether this variant is likely to be causal, we considered all 42 variants within the 99% credible set of the association, and annotated by predicted functional consequence (Supplementary Table 9)

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Determination of Michaelis-Menten constant for monobromobimane For validation of the assay, the enzymatic reaction between monobromobimane and glutathione was characterised to determine kinetic parameters such as apparent Michaelis-Menten constant and maximum rate of the reaction

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