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Overall, this trial was designed to precisely determine the dose-response relationship, efficacy, and safety of Cagrilintide compared with placebo and liraglutide, while employing advanced statistical methods to ensure reliable interpretation of treatment effects under both ideal and real-world adherence conditions

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Histology Tissue specimens from the brain, liver, spleen, stomach, duodenum, lungs and heart were obtained from rats with superior sagittal sinus ligation at 15 min (and 1, 5 and 10 min intervals thereafter), 24 h and 48 h post-ligation

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