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In contrast, in the obese ob/ob mice, both AOD9604 and hGH caused a pronounced decrease in body weight

1 2 "GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism"

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N Engl J Med 374:135145 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC (2015) NRF2 regulates serine biosynthesis in non-small cell lung cancer

It is thought that since transdifferentiation occurs adjacent to the vasculature, that the vasculature may have a signaling role in the transformation of chondrocytes to osteoblasts [16]