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in the absence of validated data, a conservative approach is appropriate discard sooner rather than later if there is any doubt Lyophilised (unreconstituted) vials should be stored according to the supplier's or trial protocol's instructions

2.2.3 Autophagy and apoptosis Autophagy is an early cellular response to METH-induced stress and is activated by the mTOR signaling pathway (Xu et al., 2018) (Figure 1)

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