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In some embodiments, a composition disclosed herein is administered on or near the round window or the crista fenestrae cochleae through entry via a post-auricular incision and surgical manipulation into or near the round window or the crista fenestrae cochleae area
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Compared to mTYR, the hTYR pocket contains more acidic amino acids, including Asp167, Asp178, Asp180, Asp286, and Glu184 (Table 1)
