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Sudden chest pain, shortness of breath, or one-sided leg swelling should not be treated as routine soreness

Note that due to the relative small size of the rats, rat fistulas regularly appeared as large and complex, and thereby, in this respect, corresponded to the worst presentation in the patients (Klicek et al., 2008

This is desirable for wound healing but theoretically problematic for patients with active malignancies or a history of angiogenesis-dependent tumors

It should be emphasised, however, that this does not constitute a scientifically validated protocol or a recommendation for use

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TB-500 has demonstrated similar positive results across various experimental paradigms