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long-term data is limited for several agents

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Dealing with the standard titration schedule The standard semaglutide titration follows a step-up protocol designed to minimize gastrointestinal side effects

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For most first-time patients we recommend: one drink, early evening, no more than 2 to 3 times per week, never on injection nights, never to the point of disrupted next-day sleep

[17] However, more studies are needed to confirm this