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Following the X-series design (Uchoa et al

It should be stressed that experimental animal models (genetically manipulated animal models, animal models obtained by destruction of certain CNS areas, and animal models obtained by using maternal factors) are indispensable for exploring the pathophysiologic causes of brain disorders, e.g., ASD, although they do not reflect the entire state of ASD disease

Chronic inflammation degrades the extracellular matrix, disrupts collagen architecture, and impairs the skin barrier function