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Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease

As a result, physicochemical parameters have been incorporated into drug discovery programs, along with other properties, to rank the lead compounds and filter out unsuitable compounds

They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition