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In vitro GSH sensitivity and selectivity experiments The HT adducts were prepared by combining the HT protein (~50 M in PBS) with the respective TRaQ-G ligand (1.52 excess, stock solution 50 mM in DMSO) and rotating the resulting solution for 1 h at 20 C

First-in-human phase I trial of the PI3Kb-selective inhibitor SAR260301 in patients with advanced solid tumors (NCT01673737)

doi: 10.1016/J.JAUT.2008.01.001 77 GeYPaisieTKNewmanJRBMcIntyreLMConcannonP

Clinical trial durations included 30-day minimum treatment courses, 12-week studies for skin rejuvenation, and 6-month protocols for hair growth (topical)

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