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were the first to show that oral administration of Lactobacillus engineered to express full-length GLP-1 (137) could induce intestinal epithelial cells to transdifferentiate into insulin-producing cells, restoring up to 33% of normal insulin secretory activity

Studies also indicate that DSIP could affect various systems in the body, including the endocrine and immune systems, with possible benefits like reducing oxidative stress, stabilizing blood pressure, and supporting mitochondrial function

Metabolism 43 , 872877 (1994)

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Immune cells and their associated cytokines in the TME exhibit a dual capacity to modulate ferroptosis in cancer cells