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It's frequently referenced alongside MOTS-c and NAD+ in research contexts, given the complementary nature of their respective pathway interactions - particularly how NNMT inhibition influences NAD+ availability in metabolic signalling studies
Research interest in this peptide centers on its selectivity: it does not appear to elevate IGF-1 levels in studied models, distinguishing it mechanistically from full growth hormone
Those pregnant, breastfeeding, or undergoing cancer treatment should avoid it until more data becomes available
There is no established evidence that continuous use is either necessary or safe over long horizons
Not for human or veterinary, diagnostic, or therapeutic use
Still, side effects from B12 supplements are possible, especially at higher doses, and include: Headache Nausea Vomiting Fatigue Weakness Diarrhea Tingling in the hands and feet Nasal spray Vitamin B12 is also available in a nasal spray
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