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High-dose thiamine (6001,800 mg/day) has shown promise in improving fatigue and pain in FM, likely by enhancing mitochondrial function and reducing oxidative stress (25)

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This approach was further applied to modification of GSH, where modification with 4-bromo-1-butene, followed by TEC afforded glycosylated GSH with 97% yield

Impact of tumor length and submucosal involvement on the long-term survival of pT1 early stage esophageal adenocarcinoma

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