Wound healing research consistently shows accelerated closure and improved collagen density versus controls
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This insight has guided Fc-engineering of IgG variants with improved pH-dependent FcRn binding, resulting in antibodies with extended plasma half-life in human FcRn transgenic mice, non-human primates (NHPs) as well as humans 10,23,24,25
All calibration data, including regression equations, are shown in Table 1
[4] A necessary caution attaches here: copper chemistry is double-edged, and a copper complex that is protective under one set of conditions can become pro-oxidant under another, which is one more reason the integrity and stoichiometry of the complex matter for how it behaves in a whole organism
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