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Tirzepatide is a single peptide that triggers the bodys receptors for GIP and GLP-1, two natural incretin hormones

10.1021/acs.jcim.2c01253 55 TolarM.HeyJ

Some research has shown that even in the absence of functional beta-3 receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting the peptide may influence brown fat or thermogenic pathways through additional mechanisms