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Since Fe(II) catalyzes the Fenton reaction to produce the free radical OH * from hydrogen peroxide, its upregulation presents a paradox: Nrf2 also boosts the expression of the genes encoding several components of the ferritin complex that detoxifies Fe(II) by converting it to Fe(III) and then stores it 22

FIGURE 1 Characterization of differentiated hepatocyte-like cells Human iPSCs were first differentiated into definitive endoderm (DE) cells, followed by hepatoblast specification and subsequent maturation into HLCs

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[Abstract]2026 Feb 25:197:119156