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Most noteworthy, the combination of cabozantinib and atezolizumab (a PD-L1 inhibitor) is now being evaluated in a phase III study of patients with advanced HCC (NCT03755791)

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Its primary characterized mechanisms include upregulation of growth factor receptors (VEGFR2, EGFR), promotion of angiogenesis through FAK-paxillin pathway activation, and modulation of nitric oxide synthesis

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