In vitro studies showed that H37Rv strain is sensitive to GSH, highlighting its potential for intracellular M.tb control [93]
Inhibition of GCH1 leads to a dysfunctional state of BH4 biosynthesis, resulting in ROS accumulation and ferroptosis (41)
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Epitalon demonstrated its strongest interaction with histone H1/6, forming 12 docking solutions at site 5 and binding with the lowest energy recorded in the study: 64.51 kcal/mol at the sequence Tyr-Arg-Lys-Thr-Gln
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