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Neuroinflammation refers to the immune systems response to injury, infection, or disease in the central nervous system

177,178,179 Meanwhile, the transcript levels of genes involved in mitochondrial protein import, such as Tomm40l, Timm44, and Timm8a1, and the transcript levels of Mfn2, Opa1, Drp1, and Fis1 are decreased in PGC-1 selectively ablated skeletal myofibers

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Liver biopsies in most dogs revealed centrilobular degeneration and necrosis, with intrahepatic cholestasis but no inflammation