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Amyloid Beta 2535 induces blood-brain barrier disruption in vitro

FASEB J (2020) 34(7):892040

PAMAM/PTM NPs and PLGA/PTM NPs at 0.125 g/mL and 0.25 g/mL decreased 95.0% and 93.9% in biofilm formation, respectively

FSEN1 was identified as a small-molecule inhibitor of FSP1 through chemical screening 118 , and subsequent structural analyses revealed that FSEN1 occupies the substrate-binding pocket of FSP1 in a position analogous to CoQ observed in the enzyme active site, providing structural insight into inhibitor recognition 119

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