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The agency said such discrepancies raise concerns about the safety of the trial subjects and the reliability of the trial data.

2011;13 Suppl 1:S4

Risk vs benefit analysis

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(A, B) Macrophages were isolated from C57BL/6 WT, MAVS -/- or double knock-out TLR2/9 -/- mice and cultured in vitro

In addition, however, some of the backbone amide protons of residues Val1264-His1271, which are more removed from the spin label site also had significant PRE effects