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1,2 Although the clinical diagnosis of PD relies on the appearance of motor manifestations, extensive neuropathological dissemination initiates decades earlier, posing a significant challenge for early diagnosis

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In the presence of OsDHAR, there was a significant increase in CAT enzymatic activity compared to in the presence of LYS or CRY, which were used as negative and positive controls, respectively (Fig

Similarly, in the PONDER and DO-HEALTH trials, no additive or synergistic effects were detected across cognitive, physical, or functional outcomes, despite adequate dosing and high adherence

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