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Babula, P., et al

Decreased ATP synthesis is phenotypically expressed during increased energy demand in fibroblasts containing mitochondrial tRNA mutations: implications for neurodegenerative and mitochondrial DNA diseases

proposed the HIF-1/ROS/VEGF pathway

This finding further supports the notion that circulating caspase-cleaved CK-18 fragments serve as a valuable diagnostic biomarker for MASH progression