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Blocking the tumor endothelial marker TEM8/anthrax toxin receptor 1 using antibodies raised against the extracellular domain inhibited angiogenesis, decreased growth of human tumor xenografts and increased the effect of anticancer drugs [322]

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Cytotoxicity assessment The biocompatibility of the SHBG treatment was assessed with a resazurin-based test alamarBlue Cell Viability Reagent (DAL1100, Invitrogen, Massachusetts, USA)