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Standard protocols involve initial loading doses followed by maintenance therapy

Modulates gene expression linked to tissue regeneration

Due to great success, DBS (Deep brain stimulation) in the subthalamic nucleus (STN) and globuspallidus internus (GPi) is currently the most popular therapy (Rocchi et al., 2012

The mechanisms of action of Pycnogenol were explored in several in vitro , in vivo and in clinical studies over the years (27)

This receptor binding increases intracellular cAMP and activates neuropeptide pathways, promoting satiety that leads to lower caloric intake in animal feeding studies