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this passive diffusion mechanism, which is though very limited for drug delivery purposes, is commonly used by highly lipid soluble substances with molecular weights less than 400500 Da, or small hydrophilic molecules such as sucrose (Wong et al., 2019)

Brevetti, G., di Lisa, F., Perna, S., Menabo, R., Barbato, R., Martone, V

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Intralesional injection therapy for Peyronies disease is commonly used as a first-line therapy along with oral medications