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Abstract FOXOs constitute a class of evolutionarily conserved transcription factors that play pivotal roles in diverse cellular processes, including glucose and lipid metabolism, energy homeostasis, oxidative stress response, and autophagy

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This method presents several advantages such as to be less consuming in term of time and money as well as its capacity to increase the potential of drugs association, by modeling the combination of different molecules

Use a Potassium Citrate Supplement: Studies have shown that potassium citrate helps to reduce kidney stone formation (30, 31)

As OxS plays an important role in PSC activation and fibrosis, the use of antioxidants to inhibit OxS is valued by researchers [36, 37]

Further striking similarities were observed with the rat neutrophil peptide NP-2 (82.8%) and -defensin 4 of the rhesus monkey (79.1%)